PREVENTION OF H-AGGREGATES FORMATION IN CY5 LABELED MACROMOLECULES

Prevention of H-Aggregates Formation in Cy5 Labeled Macromolecules

H-aggregates of the cyanine dye Cy5 are formed during covalent linkage to the cationic macromolecule Poly(allylamine) (PAH).The nonfluorescent H-aggregates strongly restrict the usage of the dye for analytical purposes and prevent Drawers a quantitative determination of the labeled macromolecules.The behavior of the H-aggregates has been studied by

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Fractures in sub-Saharan Africa: epidemiology, economic impact and ethnography (Fractures-E3): study protocol [version 1; peer review: 2 approved]

Background: The population of older adults is growing in sub-Saharan Africa.Ageing exponentially increases fragility fracture risk.Of all global regions, Africa is projected to observe the greatest increase in fragility fractures.Fractures cause pain, disability and sometimes death, and management is expensive, often requiring complex healthcare de

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The process of behavioral change in individuals who are uninterested in health: a qualitative study based on professional health knowledge

Background: In Japan and elsewhere, there is major concern over individuals who are uninterested in health and reluctant to change their health behaviors.While previous studies have investigated cognitive and behavioral characteristics in this population, there is limited evidence on whether they recognize the significance of health, nor is it clea

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